Centre of Research Excellence
Advancing AI-enabled
Clinical Decision Support
Maximising benefits and minimising risks of AI-enabled clinical decision support using a human factors and ergonomics approach
The use of artificial intelligence (AI)-enabled clinical decision support (CDS) systems is rapidly on the rise in healthcare.
AI-enabled CDS leverages advanced data analytics, machine learning, and considers a broader context (i.e. patient data) than basic CDS, presenting extraordinary potential to transform care delivery. However, this relies on AI systems being well-designed, well-understood by end-users, and aligned with clinician workflow.
Our Centre of Research Excellence will use a Human Factors and Ergonomics (HFE) approach to optimise design and implementation of AI-enabled Clinical Decision Support.
What is
Human Factors and
Ergonomics (HFE)?
HFE is the scientific discipline that ensures systems or tools are designed around the capabilities, limitations, needs and preferences of users.
HFE experts apply theory, principles, data, and methods to design/redesign technologies, work systems and environments to optimise both human well-being and system performance.
Despite the acknowledged and critical role of HFE in the design of safe, ethical and effective AI, there has been little in the way of explicit guidance available on how to achieve key AI safety principles, and to date, HFE has not been adequately considered or incorporated in AI-enabled CDS design and implementation.
Our Vision
Our Centre of Research Excellence in Human Factors and AI-enabled Clinical Decision Support will create a paradigm shift in the way AI-enabled CDS is designed, implemented, evaluated and used, to achieve our vision of maximising benefits and minimising risks of AI-enabled CDS.
About us
Our expertise
CRE Chief Investigators include world experts in HFE, both in healthcare and other safety-critical industries, clinical decision support, patient safety, HFE method development, evaluation and translation, clinical care, and artificial intelligence.
Our CRE program is designed to enhance existing collaborations and enable new collaborations with research being led from three research hubs: 1) The University of Sydney 2) Macquarie University and 3) The University of the Sunshine Coast.

Centre of Research Excellence
Our work
Figure 1. Overview of CRE in HF and AI-enabled CDS
Our proposed program of work is partner driven, highly applied and translational, and work will be conducted in partnership with our health partners (Local Health Districts, Aged care facilities), government (Australian Digital Health Agency, NSW Health, QLD Health) and associations (HFESA, CIEHF, IEA) collaborators, and primarily be undertaken in health service organisations.
We will initiate new strategies and programs to support early and mid-career researchers, and emerging leaders in healthcare HFE.
Find out more
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